Thursday 6 December 2012

A potential new clinical test of accelerated long-term forgetting



Patients with significant memory problems are assessed with a range of standard memory tests which generally demonstrate that, while the individual can retain the information for a few seconds or minutes, within half an hour, there has been substantial forgetting. However, a class of patients has recently been reported in the literature who pass these standard tests but complain of memory problems with the forgetting becoming obvious a few days or weeks later. This disorder has been termed 'Accelerated Long-Term Forgetting' or ALF and to date there is no clear clinical test to objectively demonstrate and quantify this phenomenon. In 2010, we published a single case study of a patient who shows a classic ALF profile and this new paper is a follow-up one in which we describe a memory test that we have developed that captures our patient's forgetting within an hour of first learning any information. This work came out of Terry McGibbon's Graduate Diploma dissertation and is potentially very important because due to time and financial constraints, most clinicians might see a patient only once rather than being able to reevaluate them a few days or weeks later. If our patient is representative of other ALF patients, then with this new test, a clinician can therefore test for forgetting within one clinical testing session. This may have significant implications for the patient’s diagnosis and subsequent treatment.

Ashok Jansari

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